Ammonia → HCID 69069761, compound

HRID 2109015Notes

Reaction equation

HRID 2109015 reaction equation
[C:1]([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([Cl:13])[CH:11]=2)[CH2:6][C:5]1=[O:14])(=[O:3])[CH3:2].[N+:15]([O-])([O-:17])=[O:16].[NH4+].N>S(=O)(=O)(O)O>[C:1]([N:4]1[C:12]2[C:7](=[CH:8][C:9]([N+:15]([O-:17])=[O:16])=[C:10]([Cl:13])[CH:11]=2)[CH2:6][C:5]1=[O:14])(=[O:3])[CH3:2]

Participants

5

Reactant 3

HCID 222AmmoniaHCID 22985Ammonium nitrateHCID 116441611-Acetyl-6-chloro-1,3-dihydro-2H-indol-2-one

Product 1

HCID 69069761HCID 69069761, compound

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidSolvent

Procedure

2.75 g 1-acetyl-6-chloro-2-indolinone (educt V.1) are placed in 40 ml concentrated sulphuric acid and at −10° C. 1.05 g of ammonium nitrate are added. The mixture is stirred for 1.5 hours at ambient temperature. After this time the mixture is poured onto ice water and stirred for a further 20 minutes. The solution is neutralised with concentrated ammonia, the precipitate formed is suction filtered and washed with a little ethanol and ether.

Workup

  1. additionAfter this time the mixture is poured onto ice water
  2. stirringstirred for a further 20 minutes
  3. customthe precipitate formed
  4. filtrationfiltered
  5. washwashed with a little ethanol and ether

Sources & evidence

ORD record
ord-9d2f134093514e13a6a54a79e9378994
Source dataset
uspto-grants-2009_04
Patent number
US07514468B2

Reaction notes

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