反应详情

2.75 g 1-acetyl-6-chloro-2-indolinone (educt V.1) are placed in 40 ml concentrated sulphuric acid and at −10° C. 1.05 g of ammonium nitrate are added. The mixture is stirred for 1.5 hours at ambient temperature. After this time the mixture is poured onto ice water and stirred for a further 20 minutes. The solution is neutralised with concentrated ammonia, the precipitate formed is suction filtered and washed with a little ethanol and ether.

1. additionAfter this time the mixture is poured onto ice water
2. stirringstirred for a further 20 minutes
3. customthe precipitate formed
4. filtrationfiltered
5. washwashed with a little ethanol and ether