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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2109076Generated: October 31, 2026

Cyclopropanemethanamine → N2-[4-Cyano-3-(trifluoromethyl)phenyl]-N1-(cyclopropyl methyl)-N2-ethylglycinamide

https://huagongshe.com/reaction/2109076

Reaction equation

Participants

RoleNameHCIDCharge
ReactantCyclopropanemethanamineHCID 75646—
ReactantN-[4-cyano-3-(trifluoromethyl)phenyl]-N-ethylglycineHCID 11380252—
ProductN2-[4-Cyano-3-(trifluoromethyl)phenyl]-N1-(cyclopropyl methyl)-N2-ethylglycinamideHCID 11461512—

Reaction Steps

Synthesized as described in example 3 using N-[4-cyano-3-(trifluoromethyl)phenyl]-N-ethylglycine and 1-cyclopropylmethanamine: 1H NMR (400 MHz, CDCl3) δ 7.63 (d, J=8.8 Hz, 1H), 6.96 (d, J=2.6 Hz, 1H), 6.79 (dd, J=8.8, 2.8 Hz, 1H), 6.06 (bs, 1H), 3.97 (s, 2H), 3.56 (q, J=7.1 Hz, 2H), 3.13 (t, J=6.3 Hz, 2H), 1.26 (t, J=7.1 Hz, 3H), 0.87 (m, 1H), 0.45 (m, 2H), 0.14 (m, 2H).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07514470B2
Source datasetuspto-grants-2009_04
ORD IDord-524def11940b4edd963663394fe80624
Source noteuspto-grants-2009_04