HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclopropanemethanamine → N2-[4-Cyano-3-(trifluoromethyl)phenyl]-N1-(cyclopropyl methyl)-N2-ethylglycinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclopropanemethanamine | HCID 75646 | — |
| Reactant | N-[4-cyano-3-(trifluoromethyl)phenyl]-N-ethylglycine | HCID 11380252 | — |
| Product | N2-[4-Cyano-3-(trifluoromethyl)phenyl]-N1-(cyclopropyl methyl)-N2-ethylglycinamide | HCID 11461512 | — |
Reaction Steps
Synthesized as described in example 3 using N-[4-cyano-3-(trifluoromethyl)phenyl]-N-ethylglycine and 1-cyclopropylmethanamine: 1H NMR (400 MHz, CDCl3) δ 7.63 (d, J=8.8 Hz, 1H), 6.96 (d, J=2.6 Hz, 1H), 6.79 (dd, J=8.8, 2.8 Hz, 1H), 6.06 (bs, 1H), 3.97 (s, 2H), 3.56 (q, J=7.1 Hz, 2H), 3.13 (t, J=6.3 Hz, 2H), 1.26 (t, J=7.1 Hz, 3H), 0.87 (m, 1H), 0.45 (m, 2H), 0.14 (m, 2H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07514470B2 |
| Source dataset | uspto-grants-2009_04 |
| ORD ID | ord-524def11940b4edd963663394fe80624 |
| Source note | uspto-grants-2009_04 |