Dipropylamine → HCID 11451110, compound

HRID 2109077Notes

Reaction equation

HRID 2109077 reaction equation
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([N:9]([CH2:14][CH3:15])[CH2:10][C:11]([OH:13])=O)=[CH:5][C:4]=1[C:16]([F:19])([F:18])[F:17])#[N:2].[CH2:20]([NH:23][CH2:24][CH2:25][CH3:26])[CH2:21][CH3:22]>>[C:1]([C:3]1[CH:8]=[CH:7][C:6]([N:9]([CH2:14][CH3:15])[CH2:10][C:11]([N:23]([CH2:24][CH2:25][CH3:26])[CH2:20][CH2:21][CH3:22])=[O:13])=[CH:5][C:4]=1[C:16]([F:19])([F:18])[F:17])#[N:2]

Participants

3

Reactant 2

HCID 8902DipropylamineHCID 11380252N-[4-cyano-3-(trifluoromethyl)phenyl]-N-ethylglycine

Product 1

HCID 11451110HCID 11451110, compound

Procedure

Synthesized as described in example 3 using N-[4-cyano-3-(trifluoromethyl)phenyl]-N-ethylglycine and dipropylamine: 1H NMR (400 MHz, CDCl3) δ 7.55 (d, J=9.0 Hz, 1H), 6.76 (d, J=2.5 Hz, 1H), 6.65 (dd, J=8.8, 2.5 Hz, 1H), 4.14 (s, 2H), 3.51 (m, 2H), 3.31 (t, J=7.5 Hz, 2H), 3.25 (t, J=6.7 Hz, 2H), 1.63 (m, 4H), 1.25 (t, J=7.1 Hz, 3H), 1.00 (t, J=7.3 Hz, 3H), 0.88 (t, J=7.4 Hz, 3H).

Workup

  1. customSynthesized

Sources & evidence

ORD record
ord-57db78c77897481a93563680edc2908f
Source dataset
uspto-grants-2009_04
Patent number
US07514470B2

Reaction notes

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