Methyl 2-bromopropionate → HCID 11772599, compound

HRID 2109083Notes

Reaction equation

HRID 2109083 reaction equation
[F:1][C:2]([F:18])([F:17])[CH2:3][NH:4][C:5]1[CH:12]=[CH:11][C:8]([C:9]#[N:10])=[C:7]([C:13]([F:16])([F:15])[F:14])[CH:6]=1.Br[CH:20]([CH3:25])[C:21]([O:23][CH3:24])=[O:22]>>[C:9]([C:8]1[CH:11]=[CH:12][C:5]([N:4]([CH2:3][C:2]([F:17])([F:18])[F:1])[C@H:20]([C:21]([O:23][CH3:24])=[O:22])[CH3:25])=[CH:6][C:7]=1[C:13]([F:16])([F:14])[F:15])#[N:10]

Participants

3

Reactant 2

HCID 95576Methyl 2-bromopropionateHCID 431385374-((2,2,2-Trifluoroethyl)amino)-2-(trifluoromethyl)benzonitrile

Product 1

HCID 11772599HCID 11772599, compound

Procedure

Synthesized according to step B of example 1 using 4-[(2,2,2-trifluoroethyl)amino]-2-(trifluoromethyl)benzonitrile and methyl 2-bromopropanoate: 1H NMR (400 MHz, CDCl3) δ 7.66 (d, J=8.8 Hz, 1H), 7.1 (d, J=2.7 Hz, 1H), 6.95 (dd, J=8.8, 2.7 Hz, 1H), 4.5 (q, J=7.3 Hz, 1H), 4.02-4.13 (m, 2H), 3.74 (s, 3H), 1.64 (d, J=7.1 Hz, 3H).

Workup

  1. customSynthesized

Sources & evidence

ORD record
ord-466c291b619a448aa8890096c0eea3ae
Source dataset
uspto-grants-2009_04
Patent number
US07514470B2

Reaction notes

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