Ammonia → HCID 11360164, compound

HRID 2109088Notes

Reaction equation

HRID 2109088 reaction equation
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([N:9]([CH2:16][C:17]([F:20])([F:19])[F:18])[CH:10]([CH2:14][CH3:15])[C:11]([OH:13])=O)=[CH:5][C:4]=1C(F)(F)F)#[N:2].[NH3:25]>>[C:1]([C:3]1[CH:8]=[CH:7][C:6]([N:9]([CH2:16][C:17]([F:18])([F:19])[F:20])[CH:10]([CH2:14][CH3:15])[C:11]([NH2:25])=[O:13])=[CH:5][C:4]=1[C:17]([F:20])([F:19])[F:18])#[N:2]

Participants

3

Reactant 2

HCID 222AmmoniaHCID 11382651HCID 11382651, compound

Product 1

HCID 11360164HCID 11360164, compound

Procedure

Synthesized as described in example 3 using 2-[[4-cyano-3-(trifluoromethyl)phenyl](2,2,2-trifluoroethyl)amino]butanoic acid and ammonia: 1H NMR (400 MHz, CDCl3) δ 7.60 (d, J=9.0 Hz, 1H), 7.17 (d, J=2.6 Hz, 1H), 7.03 (dd, J=9.0, 2.8 Hz, 1H), 6.38 (bs, 1H), 6.27 (bs, 1H), 4.25-4.04 (m, 3H), 2.15 (m, 1H), 1.91 (m, 1H), 0.99 (t, J=7.4 Hz, 3H).

Workup

  1. customSynthesized

Sources & evidence

ORD record
ord-6ad96d6be22945f2a5eee012ba6e11fc
Source dataset
uspto-grants-2009_04
Patent number
US07514470B2

Reaction notes

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