Cyclopropanemethanamine → HCID 11473238, compound

HRID 2109090Notes

Reaction equation

HRID 2109090 reaction equation
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([N:9]([CH2:14][CH2:15][CH3:16])[CH2:10][C:11]([OH:13])=O)=[CH:5][C:4]=1[C:17]([F:20])([F:19])[F:18])#[N:2].[CH:21]1([CH2:24][NH2:25])[CH2:23][CH2:22]1>>[C:1]([C:3]1[CH:8]=[CH:7][C:6]([N:9]([CH2:14][CH2:15][CH3:16])[CH2:10][C:11]([NH:25][CH2:24][CH:21]2[CH2:23][CH2:22]2)=[O:13])=[CH:5][C:4]=1[C:17]([F:20])([F:19])[F:18])#[N:2]

Participants

3

Reactant 2

HCID 75646CyclopropanemethanamineHCID 11243130HCID 11243130, compound

Product 1

HCID 11473238HCID 11473238, compound

Procedure

Synthesized as described in example 3 using N-[4-cyano-3-(trifluoromethyl)phenyl]-N-propylglycine and 1-cyclopropylmethane amine: 1H NMR (400 MHz, CDCl3) δ 7.62 (d, J=8.8 Hz, 1H), 6.93 (d, J=2.6 Hz, 1H), 6.77 (dd, J=8.8, 2.8 Hz, 1H), 6.00 (bs, 1H), 3.99 (s, 2H), 3.43 (t, J=7.7 Hz, 2H), 3.12 (t, J=6.8 Hz, 2H), 1.70 (m, 2H), 0.99 (t, J=7.5 Hz, 3H), 0.87 (m, 1H), 0.44 (m, 2H), 0.13 (m, 2H).

Workup

  1. customSynthesized

Sources & evidence

ORD record
ord-aca9f7b8e9f84341a434745c69c64218
Source dataset
uspto-grants-2009_04
Patent number
US07514470B2

Reaction notes

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