Ethylamine → HCID 86614371, compound

HRID 2109095Notes

Reaction equation

HRID 2109095 reaction equation
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([N:9]([CH2:15][CH:16]2[CH2:18][CH2:17]2)[C@H:10]([C:12]([OH:14])=O)[CH3:11])=[CH:5][C:4]=1[C:19]([F:22])([F:21])[F:20])#[N:2].[CH2:23]([NH2:25])[CH3:24]>>[C:1]([C:3]1[CH:8]=[CH:7][C:6]([N:9]([CH2:15][CH:16]2[CH2:17][CH2:18]2)[C@H:10]([C:12]([NH:25][CH2:23][CH3:24])=[O:14])[CH3:11])=[CH:5][C:4]=1[C:19]([F:22])([F:20])[F:21])#[N:2]

Participants

3

Reactant 2

HCID 6341EthylamineHCID 11278376HCID 11278376, compound

Product 1

HCID 86614371HCID 86614371, compound

Procedure

Synthesized as described in example 3 using N-[4-cyano-3-(trifluoromethyl)phenyl]-N-(cyclopropylmethyl)alanine and ethylamine: 1H NMR (400 MHz, CDCl3) δ 7.53 (d, J=8.8 Hz, 1H), 7.04 (d, J=2.4 Hz, 1H), 6.84 (dd, J=8.8, 2.7 Hz, 1H), 6.33 (bs, 1H), 4.27 (q, J=7.2 Hz, 1H), 3.40-3.20 (m, 4H), 1.51 (d, J=7.1 Hz, 3H), 1.05 (t, J=7.3 Hz, 3H), 1.04 (m, 1H), 0.68 (m, 2H), 0.34 (m, 2H).

Workup

  1. customSynthesized

Sources & evidence

ORD record
ord-0a4e52395eda41c992364f71d309cfc7
Source dataset
uspto-grants-2009_04
Patent number
US07514470B2

Reaction notes

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