Dimethylamine → HCID 68583815, compound

HRID 2109096Notes

Reaction equation

HRID 2109096 reaction equation
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([N:9]([CH2:15][CH:16]2[CH2:18][CH2:17]2)[C@H:10]([C:12]([OH:14])=O)[CH3:11])=[CH:5][C:4]=1[C:19]([F:22])([F:21])[F:20])#[N:2].[CH3:23][NH:24][CH3:25]>>[C:1]([C:3]1[CH:8]=[CH:7][C:6]([N:9]([CH2:15][CH:16]2[CH2:18][CH2:17]2)[C@H:10]([C:12]([N:24]([CH3:25])[CH3:23])=[O:14])[CH3:11])=[CH:5][C:4]=1[C:19]([F:22])([F:20])[F:21])#[N:2]

Participants

3

Reactant 2

HCID 674DimethylamineHCID 11278376HCID 11278376, compound

Product 1

HCID 68583815HCID 68583815, compound

Procedure

Synthesized as described in example 3 using N-[4-cyano-3-(trifluoromethyl)phenyl]-N-(cyclopropylmethyl)alanine and dimethylamine: 1H NMR (400 MHz, CDCl3) δ 7.64 (d, J=8.8 Hz, 1H), 7.10 (d, J=2.5 Hz, 1H), 6.95 (dd, J=8.8, 2.6 Hz, 1H), 4.63 (q, J=6.6 Hz, 1H), 3.19 (m, 2H), 2.98 (s, 3H), 2.90 (s, 3H), 1.38 (d, J=6.8 Hz, 3H), 0.93 (m, 1H), 0.57 (m, 2H), 0.26 (m, 2H).

Workup

  1. customSynthesized

Sources & evidence

ORD record
ord-9258cabffe7241999b5a049a31f67e29
Source dataset
uspto-grants-2009_04
Patent number
US07514470B2

Reaction notes

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