2-Chloro-5-ethynylpyridine → 3-Ethynyl-2-methylpyridine

HRID 2109161Notes

Reaction equation

HRID 2109161 reaction equation
[CH3:1][C:2]1[C:7](OS(C(F)(F)F)(=O)=O)=[CH:6][CH:5]=[CH:4][N:3]=1.Cl[C:17]1[CH:22]=CC(C#C)=CN=1>>[CH3:1][C:2]1[C:7]([C:17]#[CH:22])=[CH:6][CH:5]=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 106542812-Chloro-5-ethynylpyridineHCID 107764652-Methylpyridin-3-yl trifluoromethanesulfonate

Product 1

HCID 145265873-Ethynyl-2-methylpyridine

Procedure

2-Methyl-3-ethynyl pyridine was prepared from trifluoro-methanesulfonic acid 2-methyl-pyridin-3-yl ester in the same manner as 2-chloro-5-ethynyl-pyridine (Example 1).

Sources & evidence

ORD record
ord-d40912fae6384cc19e6325acee120a8d
Source dataset
uspto-grants-2009_04
Patent number
US07514458B2

Reaction notes

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