3-Ethynylpyridine → 4-Methyl-3-(4-pyridin-3-yl-1,2,3-triazol-1-yl)-benzoic acid

HRID 2109164Notes

Reaction equation

HRID 2109164 reaction equation
N(C1C=C(C=CC=1C)C(O)=O)=[N+]=[N-].C(C1C=NC=CC=1)#C.Cl[C:23]1[N:28]=[CH:27][C:26]([C:29]2[N:30]=[N:31][N:32]([C:34]3[CH:35]=[C:36]([CH:40]=[CH:41][C:42]=3[CH3:43])[C:37]([OH:39])=[O:38])[CH:33]=2)=[CH:25][CH:24]=1>>[CH3:43][C:42]1[CH:41]=[CH:40][C:36]([C:37]([OH:39])=[O:38])=[CH:35][C:34]=1[N:32]1[CH:33]=[C:29]([C:26]2[CH:27]=[N:28][CH:23]=[CH:24][CH:25]=2)[N:30]=[N:31]1

Participants

4

Reactant 3

HCID 1860033-EthynylpyridineHCID 179730913-Azido-4-methylbenzoic acidHCID 210972923-[4-(6-Chloro-pyridin-3-yl)-1,2,3-triazol-1-yl]-4-methyl-benzoic acid

Product 1

HCID 210973314-Methyl-3-(4-pyridin-3-yl-1,2,3-triazol-1-yl)-benzoic acid

Procedure

4-Methyl-3-(4-pyridin-3-yl-[1,2,3]triazol-1-yl)-benzoic acid was prepared from 3-azido-4-methyl benzoic acid and 3-ethynyl pyridine (Aldrich) in the same manner as 3-[4-(6-chloro-pyridin-3-yl)-1,2,3-triazol-1-yl]-4-methyl-benzoic acid (Example 1).

Sources & evidence

ORD record
ord-d1ad962fd76c4144a281fc1547830c3d
Source dataset
uspto-grants-2009_04
Patent number
US07514458B2

Reaction notes

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