3-Bromo-5-methoxypyridine → 3-Ethynyl-5-methoxypyridine

HRID 2109168Notes

Reaction equation

HRID 2109168 reaction equation
Br[C:2]1[CH:3]=[C:4]([O:8][CH3:9])[CH:5]=[N:6][CH:7]=1.Cl[C:11]1[CH:16]=CC(C#C)=CN=1>>[C:11]([C:2]1[CH:3]=[C:4]([O:8][CH3:9])[CH:5]=[N:6][CH:7]=1)#[CH:16]

Participants

3

Reactant 2

HCID 8171633-Bromo-5-methoxypyridineHCID 106542812-Chloro-5-ethynylpyridine

Product 1

HCID 210973493-Ethynyl-5-methoxypyridine

Procedure

5-Ethynyl-3-methoxy pyridine was prepared from 5-bromo-3-methoxy pyridine (Frontier) in the same manner as 2-chloro-5-ethynyl-pyridine (Example 1).

Sources & evidence

ORD record
ord-f60673179d644e1c8a2b6f23c48397ed
Source dataset
uspto-grants-2009_04
Patent number
US07514458B2

Reaction notes

Loading…