5-Bromo-2-methoxypyridine → 5-Ethynyl-2-methoxypyridine

HRID 2109188Notes

Reaction equation

HRID 2109188 reaction equation
Br[C:2]1[CH:3]=[CH:4][C:5]([O:8][CH3:9])=[N:6][CH:7]=1.Cl[C:11]1[CH:16]=CC(C#C)=CN=1>>[C:11]([C:2]1[CH:3]=[CH:4][C:5]([O:8][CH3:9])=[N:6][CH:7]=1)#[CH:16]

Participants

3

Reactant 2

HCID 27348955-Bromo-2-methoxypyridineHCID 106542812-Chloro-5-ethynylpyridine

Product 1

HCID 210973485-Ethynyl-2-methoxypyridine

Procedure

5-Ethynyl-2-methoxy pyridine was prepared from 5-bromo-2-methoxy-pyridine (Aldrich) in the same manner as 2-chloro-5-ethynyl-pyridine (Example 1).

Sources & evidence

ORD record
ord-4e38db3d9488441a80f3c55fb81b8f09
Source dataset
uspto-grants-2009_04
Patent number
US07514458B2

Reaction notes

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