Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetic Acid → 5-Iodo-N,N-dimethylpyridin-2-amine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetic Acid | HCID 176 | — |
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | Methyl iodide | HCID 6328 | — |
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | 2-Pyridinamine, 5-iodo- | HCID 88579 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | 5-Iodo-N,N-dimethylpyridin-2-amine | HCID 23438579 | — |
반응 단계
To a solution of 2-amino-5-iodopyridine (1.00 g; 4.55 mmol) in 10 mL of DMF was added 545 mg of 60% NaH (13.6 mmol) and 0.85 mL of iodomethane (13.6 mmol). The mixture was stirred for 14 h, and the mixture was neutralized with 1M HOAc. The mixture was extracted with Et2O, the extract was washed with water and brine, dried with MgSO4, filtered, and concentrated. Chromatography (0-25% EtOAc in hexanes) provided 700 mg (2.82 mmol) of (5-iodo-pyridin-2-yl)-dimethyl-amine.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07514458B2 |
| 출처 데이터셋 | uspto-grants-2009_04 |
| ORD ID | ord-80fed01558de43fd9487a99ecb0df7ea |
| 출처 메모 | uspto-grants-2009_04 |