HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2109227Generated: October 27, 2026
Dimethylformamide dimethyl acetal → Methyl 2-cyclopropanecarbonyl-3-dimethylamino-acrylate
https://huagongshe.com/reaction/2109227
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylformamide dimethyl acetal | HCID 78373 | — |
| Reactant | 3-Cyclopropyl-3-Oxopropionic Acid Methyl Ester | HCID 10130016 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | Methyl 2-cyclopropanecarbonyl-3-dimethylamino-acrylate | HCID 66877441 | 96.3% |
Reaction Steps
3-Cyclopropyl-3-oxo-propionic acid methyl ester (1.25 g, 8.79 mmol) was dissovled in 6.25 mL of CHCl3 and 1.17 mL (8.79 mmol) of dimethylformamide dimethyl acetal was added. The mixture was heated to 60° C. in a sealed vessel overnight. The mixuture was then cooled and concentrated to provide 1.67 g of 2-cyclopropanecarbonyl-3-dimethylamino-acrylic acid methyl ester.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07514458B2 |
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| Source dataset | uspto-grants-2009_04 |
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| ORD ID | ord-373bbc83d8f84ec8a561951454ce7f6a |
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| Source note | uspto-grants-2009_04 |
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