Ethyl 3-oxo-3-(pyridin-2-yl)propanoate → 1-Cyclopropyl-5-pyridin-2-yl-1H-pyrazole-4-carbaldehyde

HRID 2109265Notes

Reaction equation

HRID 2109265 reaction equation
O=[C:2]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][N:10]=1)[CH2:3][C:4]([O:6]CC)=O.C(O)(=O)C(O)=O.C1(NN)CC1.C1(C2[N:33]([CH:34]([CH3:36])[CH3:35])[N:32]=[CH:31]C=2C=O)CC1>>[CH:34]1([N:33]2[C:2]([C:9]3[CH:14]=[CH:13][CH:12]=[CH:11][N:10]=3)=[C:3]([CH:4]=[O:6])[CH:31]=[N:32]2)[CH2:36][CH2:35]1

Participants

4

Reactant 3

HCID 2736461Ethyl 3-oxo-3-(pyridin-2-yl)propanoateHCID 196201355-cyclopropyl-1-(propan-2-yl)-1H-pyrazole-4-carbaldehydeHCID 67509750Cyclopropylhydrazine oxalate

Product 1

HCID 210972431-Cyclopropyl-5-pyridin-2-yl-1H-pyrazole-4-carbaldehyde

Procedure

1-Cyclopropyl-5-pyridin-2-yl-1H-pyrazole-4-carbaldehyde was prepared from ethyl 3-oxo-3-pyridin-2-yl-propionate and cyclopropyl hydrazine oxalate in the same manner as 5-cyclopropyl-1-isopropyl-1H-pyrazole-4-carbaldehyde (Example 49).

Sources & evidence

ORD record
ord-4ad45754da654286bb71cbf83b781807
Source dataset
uspto-grants-2009_04
Patent number
US07514458B2

Reaction notes

Loading…