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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2109280Generated: October 30, 2026

1-(tert-Butoxycarbonyl)-4-piperidinecarboxylic acid → tert-Butyl 4-(3-ethoxy-3-oxopropanoyl)piperidine-1-carboxylate

https://huagongshe.com/reaction/2109280

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(tert-Butoxycarbonyl)-4-piperidinecarboxylic acidHCID 392871—
ReactantEthyl 3-oxo-3-(pyridin-2-yl)propanoateHCID 2736461—
Producttert-Butyl 4-(3-ethoxy-3-oxopropanoyl)piperidine-1-carboxylateHCID 6618868—

Reaction Steps

N-Boc-4-(2-Ethoxycarbonyl-acetyl)-piperidine was prepared from N-Boc-piperidine-4-carboxylic acid in the same manner as ethyl 3-oxo-3-pyridin-2-yl-propionate (Example 94).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07514458B2
Source datasetuspto-grants-2009_04
ORD IDord-21c324f34aa84582a234bb862172c1ea
Source noteuspto-grants-2009_04