N-Benzyloxycarbonyl-beta-alanine → Ethyl 5-benzyloxycarbonylamino-3-oxo-pentanoate

HRID 2109284Notes

Reaction equation

HRID 2109284 reaction equation
[C:1]([NH:11][CH2:12][CH2:13][C:14]([OH:16])=O)([O:3][CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)=[O:2].O=C(C1C=CC=CN=1)[CH2:19][C:20]([O:22][CH2:23][CH3:24])=[O:21]>>[CH2:4]([O:3][C:1]([NH:11][CH2:12][CH2:13][C:14](=[O:16])[CH2:19][C:20]([O:22][CH2:23][CH3:24])=[O:21])=[O:2])[C:5]1[CH:6]=[CH:7][CH:8]=[CH:9][CH:10]=1

Participants

3

Reactant 2

HCID 75313N-Benzyloxycarbonyl-beta-alanineHCID 2736461Ethyl 3-oxo-3-(pyridin-2-yl)propanoate

Product 1

HCID 15195445Ethyl 5-benzyloxycarbonylamino-3-oxo-pentanoate

Procedure

Ethyl 5-benzyloxycarbonylamino-3-oxo-pentanoate was prepared from N-Cbz-β-alanine in the same manner as ethyl 3-oxo-3-pyridin-2-yl-propionate (Example 94).

Sources & evidence

ORD record
ord-29a186d3e9884a4c8325eb45df65859d
Source dataset
uspto-grants-2009_04
Patent number
US07514458B2

Reaction notes

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