Ethyl 5-benzyloxycarbonylamino-3-oxo-pentanoate → [2-(4-Formyl-2-phenyl-2H-pyrazol-3-yl)-ethyl]-carbamic acid benzyl ester

HRID 2109285Notes

Reaction equation

HRID 2109285 reaction equation
[CH2:1]([O:8][C:9]([NH:11][CH2:12][CH2:13][C:14](=O)[CH2:15][C:16]([O:18]CC)=O)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(N1[CH2:34][CH2:33][CH:32]([C:35]2[N:36](C3CC3)[N:37]=[CH:38][C:39]=2[CH:40]=O)CC1)(OC(C)(C)C)=O>>[CH2:1]([O:8][C:9](=[O:10])[NH:11][CH2:12][CH2:13][C:14]1[N:36]([C:35]2[CH:32]=[CH:33][CH:34]=[CH:40][CH:39]=2)[N:37]=[CH:38][C:15]=1[CH:16]=[O:18])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 15195445Ethyl 5-benzyloxycarbonylamino-3-oxo-pentanoateHCID 21097373N-Boc-4-(2-cyclopropyl-4-formyl-2H-pyrazol-3-yl)-piperidine

Product 1

HCID 58861357[2-(4-Formyl-2-phenyl-2H-pyrazol-3-yl)-ethyl]-carbamic acid benzyl ester

Procedure

[2-(4-Formyl-2-phenyl-2H-pyrazol-3-yl)-ethyl]-carbamic acid benzyl ester was prepared from ethyl 5-benzyloxycarbonylamino-3-oxo-pentanoate in the same manner as N-Boc-4-(2-cyclopropyl-4-formyl-2H-pyrazol-3-yl)-piperidine (Example 108).

Sources & evidence

ORD record
ord-8b30b487058944ccab631d408bd92137
Source dataset
uspto-grants-2009_04
Patent number
US07514458B2

Reaction notes

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