3-Azido-4-methylbenzoic acid → 3-Azido-N-(5-tert-butyl-2-methanesulfinyl-phenyl)-4-methyl-benzamide
Reaction equation
[N:1]([C:4]1[CH:5]=[C:6]([CH:10]=[CH:11][C:12]=1[CH3:13])[C:7]([OH:9])=O)=[N+:2]=[N-:3].[C:14]([C:18]1[CH:19]=[CH:20][C:21]([S:25]([CH3:27])=[O:26])=[C:22]([NH2:24])[CH:23]=1)([CH3:17])([CH3:16])[CH3:15].N(C1C=C(C=CC=1C)C(NC1C=C(C(C)(C)C)C=C(NS(C)(=O)=O)C=1OC)=O)=[N+]=[N-]>>[N:1]([C:4]1[CH:5]=[C:6]([CH:10]=[CH:11][C:12]=1[CH3:13])[C:7]([NH:24][C:22]1[CH:23]=[C:18]([C:14]([CH3:17])([CH3:15])[CH3:16])[CH:19]=[CH:20][C:21]=1[S:25]([CH3:27])=[O:26])=[O:9])=[N+:2]=[N-:3]Participants
4
Procedure
3-Azido-N-(5-tert-butyl-2-methanesulfinyl-phenyl)-4-methyl-benzamide was prepared from 3-azido-4-methyl benzoic acid (U.S. Ser. No. 04/102,492) and 5-tert-butyl-2-methanesulfinyl-phenylamine in the same manner as 3-azido-N-(5-tert-butyl-3-methanesulfonylamino-2-methoxy-phenyl)-4-methyl-benzamide (Example 15).
Sources & evidence
- ORD record
- ord-e173c493c67040aeb712b794680240df
- Source dataset
- uspto-grants-2009_04
- Patent number
- US07514458B2
Reaction notes
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