Iodine → 7-Iodo-4-(furan-2-yl)isoindolinone

Participants

Reaction Steps

In a similar manner to Step 4 of Example 140, 7-amino-4-(furan-2-yl)isoindolinone (43.0 mg, 0.201 mmol) was dissolved in acetonitrile (4.3 mL), and the solution was treated with potassium iodide (40.0 mg, 0.241 mmol), copper iodide (46.0 mg, 0.241 mmol), iodine (61.0 mg, 0.241 mmol) and tert-butyl nitrite (0.072 mL, 0.60 mmol), followed by purification by preparative thin-layer chromatography (chloroform/acetonitrile=6/1) to obtain 7-iodo-4-(furan-2-yl)isoindolinone (37.8 mg, yield 58%).

Provenance & Evidence