Bismuth trichloride → HCID 68992465, compound

Participants

Reaction Steps

A 82.6 g quantity of 6,6-dibromo-2,2-dimethylpenam-3-carboxylic acid 1-oxide p-nitrobenzyl ester (Compound 4) [compound of the formula (1) wherein X═Y═Br, R=p-nitrobenzyl, n=1] was dissolved in 300 mL of dichloromethane. To the solution was added 115 mL of 20% aqueous solution of ammonium chloride and 36 mL of methanol with stirring. After adding 1.6 g of bismuth chloride and 10 g of aluminum powder at one time, the mixture was reacted at 40° C. for 8 hours. An organic layer was separated and concentrated by an evaporator to give 6-bromo-2,2-dimethylpenam-3-carboxylic acid 1-oxide p-nitrobenzyl ester (Compound 5) [compound of the formula (1b) wherein X═Br, Y═H, R=p-nitrobenzyl, n=1] in a yield of 65%.

Provenance & Evidence