Sodium Chloride → HCID 13174771, compound

Participants

Reaction Steps

A 20 g quantity of Compound 1 was dissolved in 75 mL of dichloromethane. To the solution was added 0.9 g of bismuth sulfate and 30 mL of 20% aqueous solution of sodium chloride with stirring. To the mixture were added each of 0.5 to 0.6 g of magnesium ribbon at intervals of 30 minutes in total amount of 4 g. The mixture was stirred at room temperature for 10 hours. Water (100 mL) was added and an orgaic layer was separated. The organic layer was washed with 5% aqueous solution of sodium chloride. The organic layer was concentrated and the residue was subjected to column chromatography (toluene:ethyl acetate=5:1) to give Compound 2 and Compound 3, respectively.

Provenance & Evidence