Phenol → 3-Bromodiphenyl ether

Participants

Reaction Conditions

Reaction Steps

A mixture of 1,3-dibromobenzene (15.7 g), phenol (8.0 g), potassium hydroxide (3.8 g, mortar-ground) and copper powder (0.1 g) was heated at reflux for 18 hours at 210° C. After cooling, the reaction mixture was mixed with toluene and successively washed with 10% aqueous sodium hydroxide and water. The toluene was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (eluent: hexane), thereby giving 6.1 g of the desired compound.

Provenance & Evidence