HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2109385Generated: October 30, 2026
Methyl 3-cyano-4-methoxybenzoate → 3-Cyano-4-hydroxybenzoic acid
https://huagongshe.com/reaction/2109385
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methyl 3-cyano-4-methoxybenzoate | HCID 2801011 | — |
| Reactant | Pyridinium chloride | HCID 10176127 | — |
| Product | 3-Cyano-4-hydroxybenzoic acid | HCID 11137463 | 80.5% |
Reaction Steps
A mixture of methyl 3-cyano-4-methoxybenzoate (70 g) and pyridine hydrochloride (128.3 g) was stirred for 1 hour at 180° C. in an oil bath. Ice-water (1 L) was added to the reaction mixture, and the thus-precipitated crystals were filtered and recrystallized from ethyl acetate, thereby giving 48.1 g of the desired compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07514452B2 |
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| Source dataset | uspto-grants-2009_04 |
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| ORD ID | ord-297cf8eef7004665a24d50ded460c15a |
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| Source note | uspto-grants-2009_04 |
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