4-Methoxybenzoic Acid → 3-(Chlorosulfonyl)-4-methoxybenzoic acid

HRID 2109389Notes

Reaction equation

HRID 2109389 reaction equation
[Cl:1][S:2]([OH:5])(=O)=[O:3].[CH3:6][O:7][C:8]1[CH:16]=[CH:15][C:11]([C:12]([OH:14])=[O:13])=[CH:10][CH:9]=1>O>[Cl:1][S:2]([C:9]1[CH:10]=[C:11]([CH:15]=[CH:16][C:8]=1[O:7][CH3:6])[C:12]([OH:14])=[O:13])(=[O:5])=[O:3]

Participants

4

Reactant 2

HCID 74784-Methoxybenzoic AcidHCID 24638Chlorosulfonic acid

Product 1

HCID 38548883-(Chlorosulfonyl)-4-methoxybenzoic acid

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To chlorosulfonic acid (20.00 ml) was added 4-methoxybenzoic acid (4.56 g) at 25° C. and stirred for 3 hours. Water was added at 0° C. to the reaction mixture, and the precipitated crystals were filtered, thereby giving 3.39 g of 3-chlorosulfonyl-4-methoxybenzoic acid.

Workup

  1. filtrationthe precipitated crystals were filtered

Sources & evidence

ORD record
ord-0a867113788845179be88574d9639272
Source dataset
uspto-grants-2009_04
Patent number
US07514452B2

Reaction notes

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