4-Hydroxy-3-(trifluoromethyl)benzoic acid → HCID 21481537, compound

HRID 2109394Notes

Reaction equation

HRID 2109394 reaction equation
C(C1C=[C:5](C=CC=1OC)[C:6](OC)=[O:7])#N.[OH:15][C:16]1[CH:24]=[CH:23][C:19]([C:20]([OH:22])=[O:21])=[CH:18][C:17]=1[C:25]([F:28])([F:27])[F:26]>>[C:6]([O:15][C:16]1[CH:24]=[CH:23][C:19]([C:20]([OH:22])=[O:21])=[CH:18][C:17]=1[C:25]([F:26])([F:27])[F:28])(=[O:7])[CH3:5]

Participants

3

Reactant 2

HCID 27751124-Hydroxy-3-(trifluoromethyl)benzoic acidHCID 2801011Methyl 3-cyano-4-methoxybenzoate

Product 1

HCID 21481537HCID 21481537, compound

Procedure

A reaction and treatment was carried out in the same manner as in Reference Example 62 except that the methyl 3-cyano-4-methoxybenzoate used in Reference Example 62 was replaced with methyl 4-methoxy-3-trifluoromethyl benzoate, thereby giving 4-hydroxy-3-trifluoromethylbenzoic acid. Using this compound, a reaction and treatment was carried out in the same manner as in Reference Example 80, thereby giving the desired compound.

Workup

  1. customA reaction and treatment
  2. customa reaction and treatment

Sources & evidence

ORD record
ord-40d72d8b81e444ada50f0f1a0fa0c433
Source dataset
uspto-grants-2009_04
Patent number
US07514452B2

Reaction notes

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