Triethylamine → HCID 68861634, compound

Participants

Reaction Conditions

Reaction Steps

Triethylamine (5.95 ml) was added dropwise to a mixture of 3,4-diphenyl-2-furancarboxylic acid (compound of Reference Example 33, 3.76 g), 3-(tert-butoxycarbonylamino)-4-methoxybenzoic acid hydrazide (compound of Reference Example 65, 4.00 g), BOP reagent (9.43 g) and DMF (40 ml) at 0° C., and the mixture was stirred overnight at 25° C. After adding water thereto, the reaction solution was diluted with chloroform. The organic layer was then successively washed with saturated aqueous sodium hydrogencarbonate solution and saturated brine, and dried over MgSO4. The solvent was evaporated under reduced pressure, and the residue was purified by silica gel column chromatography (eluent: chloroform), thereby giving 6.42 g of the desired compound. Melting point: 137-141° C. (Recrystallized from ethyl acetate/hexane)

Provenance & Evidence