Triethylamine → HCID 68864254, compound

Participants

Reaction Conditions

Reaction Steps

Methylsulfonyl chloride (0.28 ml) was added to a mixture of the compound of Example 41 (0.85 g), triethylamine (0.41 ml) and dioxane (30 ml) at 0° C., allowed to be warmed to 25° C. and stirred overnight. The reaction solution was diluted with ethyl acetate, washed with water and dried over MgSO4. The solvent was evaporated under reduced pressure, and the residue was purified by silica gel column chromatography (eluent: chloroform), thereby giving 0.95 g of the desired compound. Melting point: 180-182° C. (Recrystallized from ethyl acetate/hexane).

Provenance & Evidence