Hydrogen chloride-ethyl acetate → HCID 68863333, compound

HRID 2109420Notes

Reaction equation

HRID 2109420 reaction equation
C([O:5][C:6]([C:8]1[CH:9]=[C:10]([CH:28]=[CH:29][C:30]=1[OH:31])[C:11]([NH:13][NH:14][C:15]([C:17]1[O:18][CH:19]=[CH:20][C:21]=1[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)=[O:16])=[O:12])=[O:7])(C)(C)C.Cl.C(OCC)(=O)C>>[C:6]([C:8]1[CH:9]=[C:10]([CH:28]=[CH:29][C:30]=1[OH:31])[C:11]([NH:13][NH:14][C:15]([C:17]1[O:18][CH:19]=[CH:20][C:21]=1[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)=[O:16])=[O:12])([OH:7])=[O:5]

Participants

3

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 68864869HCID 68864869, compound

Product 1

HCID 68863333HCID 68863333, compoundYield 80.7%

Conditions

Temperature
25 °C

Procedure

The compound of Example 194 (0.2 g) was mixed with 4 M hydrochloric acid/ethyl acetate and stirred overnight at 25° C. After distilling off the solvent under reduced pressure, the residue was recrystallized from ethyl acetate/hexane, thereby giving 0.14 g of the desired compound.

Workup

  1. distillationAfter distilling off the solvent under reduced pressure
  2. customthe residue was recrystallized from ethyl acetate/hexane

Sources & evidence

ORD record
ord-bf54370f3e9c4b5bb4c43ebc70ed53c5
Source dataset
uspto-grants-2009_04
Patent number
US07514452B2

Reaction notes

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