Thiophene-3-boronic acid → HCID 57634237, compound

HRID 2109434Notes

Reaction equation

HRID 2109434 reaction equation
Br[C:2]1[S:6][C:5]([N:7]2[CH2:11][C@:10]3([CH:16]4[CH2:17][CH2:18][N:13]([CH2:14][CH2:15]4)[CH2:12]3)[O:9][C:8]2=[O:19])=[CH:4][CH:3]=1.[S:20]1[CH:24]=[CH:23][C:22](B(O)O)=[CH:21]1>>[S:20]1[CH:24]=[CH:23][C:22]([C:2]2[S:6][C:5]([N:7]3[CH2:11][C@:10]4([CH:16]5[CH2:17][CH2:18][N:13]([CH2:14][CH2:15]5)[CH2:12]4)[O:9][C:8]3=[O:19])=[CH:4][CH:3]=2)=[CH:21]1

Participants

3

Reactant 2

HCID 581760Thiophene-3-boronic acidHCID 10132189HCID 10132189, compound

Product 1

HCID 57634237HCID 57634237, compound

Procedure

The title compound was prepared by a method analogous to that described in Example 2 from (R)-3′-(5-bromothiophen-2-yl)spiro[1-azabicyclo[2.2.2]octan-3,5′-oxazolidin]-2′-one and thiophene-3-boronic acid. The title compound (118 mg) was obtained as a pale solid, m/z 347 (MH+).

Workup

  1. customThe title compound was prepared by a method analogous to

Sources & evidence

ORD record
ord-fcbe47c18006409f950859c7b1242b10
Source dataset
uspto-grants-2009_04
Patent number
US07514567B2

Reaction notes

Loading…