5-(Tributylstannyl)-1,3-thiazole → HCID 57634248, compound

HRID 2109438Notes

Reaction equation

HRID 2109438 reaction equation
Br[C:2]1[S:6][C:5]([N:7]2[CH2:11][C@:10]3([CH:16]4[CH2:17][CH2:18][N:13]([CH2:14][CH2:15]4)[CH2:12]3)[O:9][C:8]2=[O:19])=[CH:4][CH:3]=1.C([Sn](CCCC)(CCCC)[C:25]1[S:29][CH:28]=[N:27][CH:26]=1)CCC>>[S:29]1[C:25]([C:2]2[S:6][C:5]([N:7]3[CH2:11][C@:10]4([CH:16]5[CH2:17][CH2:18][N:13]([CH2:14][CH2:15]5)[CH2:12]4)[O:9][C:8]3=[O:19])=[CH:4][CH:3]=2)=[CH:26][N:27]=[CH:28]1

Participants

3

Reactant 2

HCID 27632575-(Tributylstannyl)-1,3-thiazoleHCID 10132189HCID 10132189, compound

Product 1

HCID 57634248HCID 57634248, compound

Procedure

The title compound was prepared by a method analogous to that described in Example 5 from (R)-3′-(5-bromothiophen-2-yl)spiro[1-azabicyclo[2.2.2]octan-3,5′-oxazolidin]-2′-one and 5-(tri-n-butylstannyl)thiazole. The title compound (31 mg) was obtained as a pale solid, m/z 348 (MH+).

Workup

  1. customThe title compound was prepared by a method analogous to

Sources & evidence

ORD record
ord-7168b144211647ee9f57eb45c9f499b9
Source dataset
uspto-grants-2009_04
Patent number
US07514567B2

Reaction notes

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