4-(Tri-n-butylstannyl)thiazole → HCID 57634263, compound

HRID 2109439Notes

Reaction equation

HRID 2109439 reaction equation
Br[C:2]1[S:6][C:5]([N:7]2[CH2:11][C@:10]3([CH:16]4[CH2:17][CH2:18][N:13]([CH2:14][CH2:15]4)[CH2:12]3)[O:9][C:8]2=[O:19])=[CH:4][CH:3]=1.C([Sn](CCCC)(CCCC)[C:25]1[N:26]=[CH:27][S:28][CH:29]=1)CCC>>[S:28]1[CH:29]=[C:25]([C:2]2[S:6][C:5]([N:7]3[CH2:11][C@:10]4([CH:16]5[CH2:17][CH2:18][N:13]([CH2:14][CH2:15]5)[CH2:12]4)[O:9][C:8]3=[O:19])=[CH:4][CH:3]=2)[N:26]=[CH:27]1

Participants

3

Reactant 2

HCID 27632584-(Tri-n-butylstannyl)thiazoleHCID 10132189HCID 10132189, compound

Product 1

HCID 57634263HCID 57634263, compound

Procedure

The title compound was prepared by a method analogous to that described in Example 5 from (R)-3′-(5-bromothiophen-2-yl)spiro[1-azabicyclo[2.2.2]octan-3,5′-oxazolidin]-2′-one and 4-(tri-n-butylstannyl)thiazole. The title compound (27 mg) was obtained as a pale solid, m/z 348 (MH+).

Workup

  1. customThe title compound was prepared by a method analogous to

Sources & evidence

ORD record
ord-8246d85a4a6b44a19c84d9d3e175153c
Source dataset
uspto-grants-2009_04
Patent number
US07514567B2

Reaction notes

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