Thiophene, 2,4-dibromo- → 3-(4-bromo-2-thienyl)Pyridine

HRID 2109445Notes

Reaction equation

HRID 2109445 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([C:7]2[CH:12]=[CH:11]N=C[CH:8]=2)[S:5][CH:6]=1.BrC1SC=C(Br)C=1.[N:20]1C=CC=C(B(O)O)[CH:21]=1>>[Br:1][C:2]1[CH:3]=[C:4]([C:7]2[CH:8]=[N:20][CH:21]=[CH:11][CH:12]=2)[S:5][CH:6]=1

Participants

4

Reactant 3

HCID 2724560Thiophene, 2,4-dibromo-HCID 27343783-Pyridinylboronic acidHCID 576342694-(4-Bromothiophen-2-yl)pyridine

Product 1

HCID 221807813-(4-bromo-2-thienyl)Pyridine

Procedure

The title compound was prepared by a method analogous to that described in Example 15 for the preparation of 4-bromo-2-(4-pyridyl)thiophene from 2,4-dibromothiophene and pyridine-3-boronic acid. The sub-title compound (2.30 g) was obtained as a pale solid, m/z 240, 242 (MH+).

Workup

  1. customThe title compound was prepared by a method analogous to

Sources & evidence

ORD record
ord-eb07982bf874487bac9225ab90984af5
Source dataset
uspto-grants-2009_04
Patent number
US07514567B2

Reaction notes

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