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(S)-螺[1-氮杂双环[2.2.2]辛烷-3,5'-恶唑啉]-2'-酮 → (R)-3'-[2-(2-Pyridyl)thiophen-4-yl]spiro[1-azabicyclo[2.2.2]octan-3,5'-oxazolidin]-2'-one
参与物
| 角色 | 名称 | HCID | 投料 |
|---|---|---|---|
| 反应物 | (S)-螺[1-氮杂双环[2.2.2]辛烷-3,5'-恶唑啉]-2'-酮 | HCID 5310971 | — |
| 反应物 | 2-(4-Bromothiophen-2-yl)pyridine | HCID 14292356 | — |
| 产物 | (R)-3'-[2-(2-Pyridyl)thiophen-4-yl]spiro[1-azabicyclo[2.2.2]octan-3,5'-oxazolidin]-2'-one | HCID 11473306 | — |
反应步骤
The title compound was prepared by a method analogous to that described in Preparation 3 from (S)-spiro[1-azabicyclo[2.2.2]octan-3,5′-oxazolidin]-2′-one and 4-bromo-2-(2-pyridyl)thiophene. The title compound (140 mg) was obtained as a pale-yellow solid, m/z 342 (MH+).
来源与证据
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 专利号 | US07514567B2 |
| 来源数据集 | uspto-grants-2009_04 |
| ORD ID | ord-cd123280353a49fe81c7667edc6d9e32 |
| 来源说明 | uspto-grants-2009_04 |