3-Pyridinylboronic acid → 3-(4-Bromofuran-2-yl)pyridine

HRID 2109463Notes

Reaction equation

HRID 2109463 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([C:7]2[CH:12]=[CH:11]N=C[CH:8]=2)[O:5][CH:6]=1.BrC1OC([Si](C)(C)C)=C(Br)C=1.[N:24]1C=CC=C(B(O)O)[CH:25]=1>>[Br:1][C:2]1[CH:3]=[C:4]([C:7]2[CH:8]=[N:24][CH:25]=[CH:11][CH:12]=2)[O:5][CH:6]=1

Participants

4

Reactant 3

HCID 27343783-Pyridinylboronic acidHCID 576342534-(4-Bromofuran-2-yl)pyridineHCID 576342652,4-Dibromo-5-(trimethylsilyl)furan

Product 1

HCID 576342343-(4-Bromofuran-2-yl)pyridine

Procedure

The sub-title compound was prepared by a method analogous to that described for the preparation of 4-bromo-2-(4-pyridyl)-furan from 2,4-dibromo-5-(trimethylsilyl)furan and pyridine-3-boronic acid. The sub-title compound (725 mg) was obtained as a beige solid, m/z 224,226 (MH+).

Workup

  1. customThe sub-title compound was prepared by a method analogous to

Sources & evidence

ORD record
ord-7bba37c85b834ec2b60ce82541a1d84c
Source dataset
uspto-grants-2009_04
Patent number
US07514567B2

Reaction notes

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