Tetrahydrofuran → HCID 86605667, compound

Participants

Reaction Steps

To a solution of 5-amino-1-(2,6-dichloro-4-trifluoromethylphenyl)-3-cyano-4-trifluoromethylthiopyrazole (10.0 g, 23.7 mmol) in tetrahydrofuran was added triethylamine (3.36 g, 33.2 mmol) and 4-dimethylaminopyridine (0.58 g, 4.7 mmol), followed by dropwise addition of ethyl oxalyl chloride (4.21 g, 30.9 mmol) in tetrahydrofuran at 50-70° C. The mixture was heated to reflux for 8 hours. After extractive workup (heptane-ethyl acetate, water, HCl) the title product was obtained (13.9 g).

Provenance & Evidence