Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Fipronil | HCID 3352 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Dicyclohexylcarbodiimide | HCID 10868 | — |
| Reactant | N-Benzyloxycarbonyl-beta-alanine | HCID 75313 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Solvent | Ethylacetate heptane | HCID 21899848 | — |
| Product | HCID 86605668 | HCID 86605668 | — |
Reaction Steps
To a solution of 5-amino-1-(2,6-dichloro-4-trifluoromethylphenyl)-3-cyano-4-trifluoromethylsulfinylpyrazole (1.0 g, 2.29 mmol) in dioxan, benzyloxycarbonyl-beta-alanine (0.56 g, 2.5 mmol), dicyclohexylcarbodiimide (0.61 g, 2.9 mmol) and 4-dimethylaminopyridine (0.06 g, 0.46 mmol) were added. The mixture was stirred at 25° C. for 24 hours. After extractive workup (ethyl acetate, water) and column chromatography with heptane-ethyl acetate (1:1) the title product was obtained (0.81 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07514561B2 |
|---|
| Source dataset | uspto-grants-2009_04 |
|---|
| ORD ID | ord-6a3b3e836fe7493490557a2664b627c3 |
|---|
| Source note | uspto-grants-2009_04 |
|---|
