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HRID 2109491作成日：2026年10月25日

(2S)-1-(2-bromoacetyl)pyrrolidine-2-carbonitrile → (2S)-1-[[N-[4-(2-tetrahydropyranyl)oxycarbonylbicyclo[2,2,2]oct-1-yl]amino]acetyl]pyrrolidine-2-carbonitrile

https://huagongshe.com/reaction/2109491

反応式

関与物質

役割名称HCID仕込み量
反応物(2S)-1-(2-bromoacetyl)pyrrolidine-2-carbonitrileHCID 11031276—
反応物2-Tetrahydropyranyl 4-aminobicyclo[2,2,2]octane-1-carboxylateHCID 23149698—
生成物(2S)-1-[[N-[4-(2-tetrahydropyranyl)oxycarbonylbicyclo[2,2,2]oct-1-yl]amino]acetyl]pyrrolidine-2-carbonitrileHCID 5938314867.8%

反応手順

Using 2-tetrahydropyranyl 4-aminobicyclo[2,2,2]octane-1-carboxylate (90.0 mg) and (2S)-1-(2-bromoacetyl)pyrrolidine-2-carbonitrile (70.0 mg), the same procedure was followed as in Example 1 to obtain (2S)-1-[[N-[4-(2-tetrahydropyranyl)oxycarbonylbicyclo[2,2,2]oct-1-yl]amino]acetyl]pyrrolidine-2-carbonitrile (85.2 mg).

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US07514571B2
出典データセットuspto-grants-2009_04
ORD IDord-912ecc7e0af444399c58d71fd99c88ec
出典メモuspto-grants-2009_04