HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methylbicyclo[2.2.2]octan-1-amine → (2S,4S)-1-[[N-(4-methylbicyclo[2,2,2]oct-1-yl)amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methylbicyclo[2.2.2]octan-1-amine | HCID 13184610 | — |
| Reactant | (2S,4S)-1-(2-bromoacetyl)-4-fluoropyrrolidine-2-carbonitrile | HCID 21090395 | — |
| Product | (2S,4S)-1-[[N-(4-methylbicyclo[2,2,2]oct-1-yl)amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile | HCID 11150530 | 75.6% |
Reaction Steps
Using 4-amino-1-methylbicyclo[2,2,2]octane (56.0 mg) and (2S,4S)-1-(2-bromoacetyl)-4-fluoropyrrolidine-2-carbonitrile (95.0 mg), the same procedure was followed as in Example 1 to obtain (2S,4S)-1-[[N-(4-methylbicyclo[2,2,2]oct-1-yl)amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile (89.2 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07514571B2 |
| Source dataset | uspto-grants-2009_04 |
| ORD ID | ord-ecba30abd38b4d6aa33903f4ac4e453d |
| Source note | uspto-grants-2009_04 |