2-Bromophenyl isocyanate → HCID 9910487, compound

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A mixture of 1-(6-methyl-4-trifluoromethylpyridin-2-yl)azetidin-3-ylamine, D12 (100 mg, 0.432 mM) and 2-bromophenyl isocyanate (86 mg, 0.432 mM) in dichloromethane (5 ml) was kept at room temperature overnight. The resultant solid was removed by centrifugation, washed with diethyl ether and dried in vacuo, to give the title compound as a colourless solid, (119 mg, 64%). MH+ 429 and 431; 1H NMR (250 MHz, d6DMSO) δ: 2.39 (3H, s), 3.75-3.88 (2H, dd), 4.30 (2H, t), 4.50-4.66 (1H, m), 6.48 (1H, s), 6.78 (1H,s), 6.92 (1H, m), 7.28 (1H, m), 7.57 (1H, dd), 7.76 (1H, d), 7.86 (1H, s), and 8.04 (1H, dd).

Provenance & Evidence