HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → HCID 10432375, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Phenyl chloroformate | HCID 15891 | — |
| Reactant | 3-Amino-1-(diphenylmethyl)azetidine | HCID 5744546 | — |
| Reactant | 3-Methylisoquinolin-5-amine | HCID 12212055 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 10432375 | HCID 10432375 | — |
Reaction Steps
D4 (73 mg, 0.46 mmol) in dry dichloromethane (5 ml) was treated with pyridine (45 ul, 0.55 mmol) followed by phenyl chloroformate (69 ul, 0.55 mmol). After 1 h triethylamine (128 ul, 0.92 mmol) was added, followed by D16 (0.46 mmol). The reaction mixture was then stirred overnight at ambient temperature. The precipitate was separated by centrifugation, washed with DCM, diethyl ether and then dried to give the title compound as a yellow solid. MH+ 423.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07514562B2 |
| Source dataset | uspto-grants-2009_04 |
| ORD ID | ord-993fe47287f04759ad1c56c431fbe22e |
| Source note | uspto-grants-2009_04 |