反应详情

温度

170 °C

A mixture of 35 g (0.17 mol) of 7H-dibenzo[c,e]oxepin-5-one and 30.8 g (0.17 mol) of potassium phthalimide in 330 ml of DMF was heated at 170° C. for 18 h. After cooling, the deposited precipitate was filtered off with suction and introduced into 160 ml of glacial acetic acid. After stirring for 1 h, the mixture was diluted with 650 ml of ice water and the deposited product was filtered off with suction and dried in vacuo. 44.8 g of 2′-phthalimidomethylbiphenyl-2-carboxylic acid were obtained; m.p. 198° C.

1. temperatureAfter cooling
2. filtrationthe deposited precipitate was filtered off with suction
3. additionintroduced into 160 ml of glacial acetic acid
4. additionthe mixture was diluted with 650 ml of ice water
5. filtrationthe deposited product was filtered off with suction
6. customdried in vacuo