HCID 15512340, compound → HCID 10939752, compound

HRID 2109540Notes

Reaction equation

HRID 2109540 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][CH2:8][NH:9][C:10]([C:12]1[C:13]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=2[CH2:24][NH2:25])=[CH:14][CH:15]=[CH:16][CH:17]=1)=[O:11].N1C=CC=CC=1CCNC(C1C(C2C=CC=CC=2)=CC=CC=1CN[C:45]([O:47][CH:48]([CH3:55])[C:49]1[CH:54]=[CH:53][CH:52]=[CH:51][CH:50]=1)=[O:46])=O>>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][CH2:8][NH:9][C:10]([C:12]1[C:13]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=2[CH2:24][NH:25][C:45]([O:47][C@H:48]([CH3:55])[C:49]2[CH:54]=[CH:53][CH:52]=[CH:51][CH:50]=2)=[O:46])=[CH:14][CH:15]=[CH:16][CH:17]=1)=[O:11]

Participants

3

Reactant 2

HCID 15512340HCID 15512340, compoundHCID 131727394HCID 131727394, compound

Product 1

HCID 10939752HCID 10939752, compound

Procedure

From 0.3 mmol of 2′-aminomethylbiphenyl-2-carboxylic acid 2-(2-pyridyl)-ethylamide (precursor 5d) and (R)-α-methylbenzyl N-succinimido-carbonate (precursor 4i), according to the general working procedure 60 mg of (R)-2′-(α-methylbenzyloxycarbonylaminomethylbiphenyl-2-carboxylic acid 2-(2-pyridyl)ethylamide were obtained. MS (ES+): m/e=480 (M+1).

Workup

  1. customwere obtained

Sources & evidence

ORD record
ord-97f07f08041a461d9c0ebbde8e783537
Source dataset
uspto-grants-2009_04
Patent number
US07514582B2

Reaction notes

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