3-Fluorobenzenesulfonyl Chloride → HCID 9848349, compound

HRID 2109545Notes

Reaction equation

HRID 2109545 reaction equation
[CH2:1]([NH:9][C:10]([C:12]1[C:13]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=2[CH2:24][NH2:25])=[CH:14][CH:15]=[CH:16][CH:17]=1)=[O:11])[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[F:26][C:27]1[CH:28]=[C:29]([S:33](Cl)(=[O:35])=[O:34])[CH:30]=[CH:31][CH:32]=1.C(NC(C1C(C2C=CC=CC=2C(S(C2C=CC=C(F)C=2)(=O)=O)N)=CC=CC=1)=O)CC1C=CC=CC=1>>[CH2:1]([NH:9][C:10]([C:12]1[C:13]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=2[CH2:24][NH:25][S:33]([C:29]2[CH:30]=[CH:31][CH:32]=[C:27]([F:26])[CH:28]=2)(=[O:35])=[O:34])=[CH:14][CH:15]=[CH:16][CH:17]=1)=[O:11])[CH2:2][C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1

Participants

4

Reactant 3

HCID 27342583-Fluorobenzenesulfonyl ChlorideHCID 155093842'-(Aminomethyl)-N-(2-phenylethyl)[1,1'-biphenyl]-2-carboxamideHCID 68972920HCID 68972920, compound

Product 1

HCID 9848349HCID 9848349, compound

Procedure

From 0.61 mmol of 2′-aminomethylbiphenyl-2-carboxylic acid phenethylamide (precursor 5a) and 3-fluorophenylsulfonyl chloride, according to the general working procedure 221 mg of 2′-(3-fluorophenylsulfonyl-aminomethyl)biphenyl-2-carboxylic acid phenethylamide were obtained;

Workup

  1. customwere obtained

Sources & evidence

ORD record
ord-3653cad7698f468c90a0386ce8f36daa
Source dataset
uspto-grants-2009_04
Patent number
US07514582B2

Reaction notes

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