3-Acetylbenzenesulfonyl chloride → 2'-(3-Acetylphenylsulfonylaminomethyl)biphenyl-2-carboxylic acid benzylamide

HRID 2109548Notes

Reaction equation

HRID 2109548 reaction equation
[CH2:1]([NH:8][C:9]([C:11]1[C:12]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=2[CH2:23][NH2:24])=[CH:13][CH:14]=[CH:15][CH:16]=1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:25]([C:28]1[CH:29]=[C:30]([S:34](Cl)(=[O:36])=[O:35])[CH:31]=[CH:32][CH:33]=1)(=[O:27])[CH3:26].C(NC(C1C(C2C=CC=CC=2C(S(C2C=CC=C(C(=O)C)C=2)(=O)=O)N)=CC=CC=1)=O)C1C=CC=CC=1>>[CH2:1]([NH:8][C:9]([C:11]1[C:12]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=2[CH2:23][NH:24][S:34]([C:30]2[CH:31]=[CH:32][CH:33]=[C:28]([C:25](=[O:27])[CH3:26])[CH:29]=2)(=[O:36])=[O:35])=[CH:13][CH:14]=[CH:15][CH:16]=1)=[O:10])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 27562603-Acetylbenzenesulfonyl chlorideHCID 155093852'-Aminomethylbiphenyl-2-carboxylic acid benzylamideHCID 689743542'-(3-Acetylphenylsulfonyl-aminomethyl)biphenyl-2-carboxylic acid benzylamide

Product 1

HCID 98921112'-(3-Acetylphenylsulfonylaminomethyl)biphenyl-2-carboxylic acid benzylamide

Procedure

From 0.28 mmol of 2′-aminomethylbiphenyl-2-carboxylic acid benzylamide (precursor 5b) and 3-acetylphenylsulfonyl chloride, according to the general working procedure 110 mg of 2′-(3-acetylphenylsulfonyl-aminomethyl)biphenyl-2-carboxylic acid benzylamide were obtained;

Workup

  1. customwere obtained

Sources & evidence

ORD record
ord-33f130bbce6d43b286aaca0516ad09ad
Source dataset
uspto-grants-2009_04
Patent number
US07514582B2

Reaction notes

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