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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2109564Generated: October 30, 2026

1-Boc-2-(3-amino-5-trifluoromethyl-phenoxymethyl)-pyrrolidine → 1-Boc-2-[3-[(2-Fluoro-pyridine-3-carbonyl)-amino]-5-trifluoromethyl-phenoxymethyl}-pyrrolidine

https://huagongshe.com/reaction/2109564

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Boc-2-(3-amino-5-trifluoromethyl-phenoxymethyl)-pyrrolidineHCID 21959488—
Reactant1-Boc-4-[3-[(2-fluoro-pyridine-3-carbonyl)-amino]-5-trifluoromethyl-phenoxy}-piperidineHCID 21959521—
Product1-Boc-2-[3-[(2-Fluoro-pyridine-3-carbonyl)-amino]-5-trifluoromethyl-phenoxymethyl}-pyrrolidineHCID 21959577—

Reaction Steps

1-Boc-2-{3-[(2-Fluoro-pyridine-3-carbonyl)-amino]-5-trifluoromethyl-phenoxymethyl}-pyrrolidine was prepared from 1-Boc-2-(3-amino-5-trifluoromethyl-phenoxymethyl)-pyrrolidine by a procedure similar to that described in the preparation of 1-Boc-4-{3-[(2-fluoro-pyridine-3-carbonyl)-amino]-5-trifluoromethyl-phenoxy}-piperidine.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07514564B2
Source datasetuspto-grants-2009_04
ORD IDord-6dd8c5f668a040b99e71bbe48b1e8db5
Source noteuspto-grants-2009_04