5-Fluoro-1-methyl-1H-indole-2-carboxylic acid → N-[[2-[2-amino-5-(3-fluorophenyl)-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-5-fluoro-1-methylindole-2-carboxamide

HRID 210959Notes

Reaction equation

HRID 210959 reaction equation
[F:24][c:25]1[cH:26][c:27]2[cH:28][c:29]([C:35](=[O:36])[OH:37])[n:30]([CH3:34])[c:31]2[cH:32][cH:33]1.[NH2:1][c:2]1[s:3][c:4](-[c:17]2[cH:18][c:19]([F:23])[cH:20][cH:21][cH:22]2)[c:5]([C:7](=[O:8])[N:9]2[CH:10]3[CH2:11][CH:12]3[CH2:13][CH:14]2[CH2:15][NH2:16])[n:6]1>>[NH2:1][c:2]1[s:3][c:4](-[c:17]2[cH:18][c:19]([F:23])[cH:20][cH:21][cH:22]2)[c:5]([C:7](=[O:8])[N:9]2[CH:10]3[CH2:11][CH:12]3[CH2:13][CH:14]2[CH2:15][NH:16][C:35]([c:29]2[cH:28][c:27]3[cH:26][c:25]([F:24])[cH:33][cH:32][c:31]3[n:30]2[CH3:34])=[O:36])[n:6]1

Participants

3

Reactant 2

HCID 6625465-Fluoro-1-methyl-1H-indole-2-carboxylic acidHCID 178509363HCID 178509363, compound

Product 1

HCID 178481153N-[[2-[2-amino-5-(3-fluorophenyl)-1,3-thiazole-4-carbonyl]-2-azabicyclo[3.1.0]hexan-3-yl]methyl]-5-fluoro-1-methylindole-2-carboxamide

Sources & evidence

ORD record
ord-da58ac66db954ad59b2698925647b754
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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