Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 3-Buten-1-ol | HCID 69389 | — |
| Reactant | 2-Bromo-1-tert-butyl-4-nitrobenzene | HCID 238587 | — |
| Catalyst | palladium(II) acetate | HCID 167845 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 66688391 | HCID 66688391 | — |
Reaction Steps
A mix of 1-(tert-butyl)-2-bromo-4-nitrobenzene (3.652 g), TEA (5.92 ml), 3-buten-1-ol (5.48 ml), Pd(OAc)2 (32 mg), Pd(PPh3)4 (327 mg) and toluene (40 ml) was degassed with nitrogen and heated in a sealed vessel for 16 h at 120° C. The next day, the reaction mixture was cooled to RT, filtered, and concentrated in vacuo. The crude was eluted on a silica gel column with 15% to 22% EtOAc/hexanes gradient system to yield a yellow-brown oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07514564B2 |
|---|
| Source dataset | uspto-grants-2009_04 |
|---|
| ORD ID | ord-ecde7207161449d8936be2f8f1350f43 |
|---|
| Source note | uspto-grants-2009_04 |
|---|
