6-Aminoquinoline → HCID 21959464, compound

HRID 2109599Notes

Reaction equation

HRID 2109599 reaction equation
Cl[C:2]1[N:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[NH2:11][C:12]1[CH:13]=[C:14]2[C:19](=[CH:20][CH:21]=1)[N:18]=[CH:17][CH:16]=[CH:15]2>>[N:18]1[C:19]2[C:14](=[CH:13][C:12]([NH:11][C:2]3[C:3]([C:4]([OH:6])=[O:5])=[CH:7][CH:8]=[CH:9][N:10]=3)=[CH:21][CH:20]=2)[CH:15]=[CH:16][CH:17]=1

Participants

3

Reactant 2

HCID 113736-AminoquinolineHCID 762582-Chloronicotinic acid

Product 1

HCID 21959464HCID 21959464, compound

Conditions

Temperature
140 °C

Procedure

A mixture of 2-chloronicotinic acid (1.5 g) and 6-aminoquinoline (1.4 g) was heated at 140° C. neat for 2 h. The reaction was cooled to give a brown solid used in the next step without further purification. MS (ES+): 266 (M+H)+; (ES−): 264 (M−H)−.

Workup

  1. temperatureThe reaction was cooled
  2. customto give a brown solid
  3. customused in the next step without further purification

Sources & evidence

ORD record
ord-68ea0738eb5e4f629d523ba7ec9b5d2e
Source dataset
uspto-grants-2009_04
Patent number
US07514564B2

Reaction notes

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