2-Chloronicotinic acid → HCID 21959407, compound

HRID 2109609Notes

Reaction equation

HRID 2109609 reaction equation
[NH2:1][C:2]1[CH:10]=[C:9]2[C:5]([CH:6]=[N:7][NH:8]2)=[CH:4][CH:3]=1.Cl[C:12]1[N:20]=[CH:19][CH:18]=[CH:17][C:13]=1[C:14]([OH:16])=[O:15]>>[NH:8]1[C:9]2[C:5](=[CH:4][CH:3]=[C:2]([NH:1][C:12]3[C:13]([C:14]([OH:16])=[O:15])=[CH:17][CH:18]=[CH:19][N:20]=3)[CH:10]=2)[CH:6]=[N:7]1

Participants

3

Reactant 2

HCID 762582-Chloronicotinic acidHCID 814231H-Indazol-6-amine

Product 1

HCID 21959407HCID 21959407, compound

Conditions

Temperature
150 °C

Procedure

A mixture of 6-aminoindazole (6.7 g) and 2-chloronicotinic acid (8 g) was heated neat at 150° C. for 2 h. The reaction was cooled and washed with acetone to give 2-(1H-indazol-6-ylamino)pyridine-3-carboxylic acid.

Workup

  1. temperatureThe reaction was cooled
  2. washwashed with acetone

Sources & evidence

ORD record
ord-c8d0f5f2e05c4b0ab15bf51c3b51723a
Source dataset
uspto-grants-2009_04
Patent number
US07514564B2

Reaction notes

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